Endocrine Abstracts

IntroductionGraves’ disease is the most common cause of hyperthyroidism in children and adolescents. Treatment strategy includes antithyroid drugs, radioactive iodine and thyroidectomy. The optimal treatment of Graves´ disease is still controversial. Our aim is to describe the surgical treatment of Graves’s disease in children and adolescents.Material and methodsWe report the clinical, therapeu...

ObjectiveTo highlight the diagnostic difficulties that a pathologist may encounter in identifying intra-thyroid metastasis when the primary cancer is not known.Case reportA 73-year-old woman with no specific pathological history, admitted for the management of a right mean spinal swelling that had appeared two months earlier and is gradually increasing in size. The evolution was marked by the association of d...

IntroductionParathyroid surgery is indicated essentially in primary and secondary hyperparathyroidism. This surgery may present some difficulties even in experienced hands. Our aim is to describe the difficulties that can occur during parathyroid surgery.Material and methodsA retrospective study including 81 cases of hyperparathyroidism, operated between 2001 and 2018.Results<p clas...

ObjectiveThe study’s purpose is to describe the therapeutic management of papillary thyroid microcarcinoma.Material and methodsThis is a retrospective study including 55 cases of papillary thyroid microcarcinoma treated at our department, from 2000 to 2020.ResultsOur study included 8 men and 47 women. The mean age was 48.64 years with extreme ages from 24 to ...

Authors: Mohamed Coco, Katrina Sheikh, Basheir Osman, Jayadave Shakher: Department of Acute Internal Medicine, Birmingham Heartlands Hospital-University Hospitals BirminghamIntroduction: Although skeletal metastatic diseases have commonly been associated with hypercalcemia; we present a case of severe hypercalcemia secondary to extensive skeletal sclerotic metastatic disease.Case: ...

Background: Graves’ disease (GD) is the commonest cause of primary hyperthyroidism. First-line treatment involves 12-18 months of anti-thyroid drugs (ATD). Subsequently, around 50% of patients will relapse, requiring definitive treatment. Identifying risk factors that predict relapse or treatment failure can guide management. We aimed to explore risk factors that identify patients at high risk of relapse or medical treatment failure, to allow prioritisati...

Introduction: Testosterone(T) is converted to dihydrotestosterone(DHT), the most potent androgen, by the enzyme 5alpha-reductase type 2(SRD5A2). During foetal development, the masculinisation of male external genitalia crucially depends on DHT. Pathogenic variants in SRD5A2 cause 46,XY differences in sex differentiation(DSD). Early and accurate diagnosis is paramount to facilitate gender assignment since most reared as females may profoundly virilize at pubert...

Background: Thioamide-resistant severe Graves’ thyrotoxicosis (SGT) is rare and often poor patient adherence to therapy is suspected. Management is truly challenging. Case report: 36-year-old female with SGT was referred for further management. The diagnosis was made 5 years ago following delivery of her first son. During her second pregnancy 2 years ago, she required emergency caesarean with the indication of foetal tac...

Introduction: The uncertainty surrounding the optimal dose to rectify severe vitamin D deficiency (VDD) necessitates further investigation.Aim: To review and analyze various vitamin D (VD) supplementation doses, durations, and their effects on 25-hydroxyvitamin D (25OHD) levels, along with their biochemical and clinical outcomes, in the management of VDD.Methods: We reviewed intervention studies targeting VDD from databases (PubMed...

Introduction: The relationship between early puberty and abnormal bone health has garnered significant research attention, with varying outcomes. Objectives: This review systematically examines studies up to March 2023 to determine whether early puberty is associated with abnormal bone health, specifically low bone mineral density (BMD), osteopenia, and osteoporosis. We analyze and summarize research articles (n=25) to elucidate the potential li...